Chemical composition and hepatoprotective activity of ethanolic root extract of Taraxacum Syriacum Boiss against acetaminophen intoxication in rats

Afshin Nazari, Hamed Fanaei, Ahmad Reza Dehpour, Gholamreza Reza Eza Hassanzadeh, Mahvash Jafari, Maryam Salehi, Mohsen Mohammadi


Abstract: Aim: In the present study, the role of ethanol extract of root of Taraxacum Syriacum Boiss (TSBE)against hepatotoxicity caused by acetaminophen (APAP) was studied.Methods: The chemical composition of roots of Taraxacum Syriacum Boiss was analyzed by SPME-GC/MSmethod. Hepatocellular injuries induced by acetaminophen (APAP) were assessed by liver histology, serumaminotransferase activities, antioxidant enzymes activity and lipid peroxidation in liver tissue.Results: TSBE was observed to exhibit hepatoprotective effect as demonstrated by signifi cant decrease in serumglutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), and alkalinephosphatase (ALP) concentration, and by preventing liver histopathologic changes in rats with APAP hepatotoxicity.Administration of APAP, signifi cantly increased, lactate dehydrogenase (LDH) and catalase (CAT) activity inliver tissue and pretreatment with TSBE returned these parameters to control group, moreover TSBE reducesAPAP-induced hepatic Glutathione (GSH) depletion. Carvacrol (6.7 %) was the main polyphenolic compoundof plant sample. Our results demonstrated hepatoprotective activity of TSBE in rat in vivo.Conclusions: We believe that the mechanism by which the extract was able to protect the liver from the oxidativestress generated by APAP is due to its antioxidant activity. These phenolic compounds of the extract act asantioxidants and free radical scavengers and reduce or inhibit the oxidative stress induced by APAP administration(Tab. 3, Fig. 3, Ref. 39). Text in PDF words: hepatoprotective, Taraxacum Syriacum Boiss, acetaminophen, phenolic compounds.

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