Interleukin-10 -1082A>G polymorphism and susceptibility to pulmonary Tuberculosis in Lur population of Iran

Farhad Shahsavar, Alireza Azargoon, Ali Sheikhian


Abstract. Tuberculosis (TB) is caused by Mycobacterium tuberculosis is one of the majorcauses of death. Cytokines play a major role in immune defense against such infectiousagents. Polymorphisms in the genes that encodes various cytokines have been associatedwith tuberculosis susceptibility. In this study we investigated whether IL-10 -1082A>G,-819T>C and -592A>C polymorphisms have any association with the susceptibility to pulmonaryTB in the Lur population of Iran. IL-10 polymorphism genotyping was performed by thepolymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method in100 pulmonary TB patients and 100 healthy controls of Lur population. The genotypicfrequencies of IL-10 -819T>C and -592A>C polymorphisms did not vary significantly betweenTB patients and healthy controls. Only, in IL-10 -1082A>G polymorphism, a significantlyincreased frequency of genotype AG was observed among patients compared with controls(74% in the patients vs. 58% in the controls, P=0.0252, OR=0.485, CI=0.4307-0.5988). Theallelic frequencies of IL-10 -1082A>G, -819T>C and -592A>C polymorphisms did not havesignificant difference between the pulmonary TB patients and the healthy controls. Ourresults demonstrate that the IL-10 -1082A>G polymorphism may be a valuable marker topredict the risk for the development of TB in the Lur population of Iran.

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