Interleukin-10 -1082A>G polymorphism and susceptibility to pulmonary Tuberculosis in Lur population of Iran

چکیده

Abstract. Tuberculosis (TB) is caused by Mycobacterium tuberculosis is one of the majorcauses of death. Cytokines play a major role in immune defense against such infectiousagents. Polymorphisms in the genes that encodes various cytokines have been associatedwith tuberculosis susceptibility. In this study we investigated whether IL-10 -1082A>G,-819T>C and -592A>C polymorphisms have any association with the susceptibility to pulmonaryTB in the Lur population of Iran. IL-10 polymorphism genotyping was performed by thepolymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method in100 pulmonary TB patients and 100 healthy controls of Lur population. The genotypicfrequencies of IL-10 -819T>C and -592A>C polymorphisms did not vary significantly betweenTB patients and healthy controls. Only, in IL-10 -1082A>G polymorphism, a significantlyincreased frequency of genotype AG was observed among patients compared with controls(74% in the patients vs. 58% in the controls, P=0.0252, OR=0.485, CI=0.4307-0.5988). Theallelic frequencies of IL-10 -1082A>G, -819T>C and -592A>C polymorphisms did not havesignificant difference between the pulmonary TB patients and the healthy controls. Ourresults demonstrate that the IL-10 -1082A>G polymorphism may be a valuable marker topredict the risk for the development of TB in the Lur population of Iran.